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Merck
모든 사진(2)

문서

SAB4503785

Sigma-Aldrich

Anti-phospho-Trk B (pTyr515) antibody produced in rabbit

affinity isolated antibody

동의어(들):

Anti-DEE58, Anti-EIEE58, Anti-GP145-TrkB, Anti-OBHD, Anti-TRKB, Anti-trk-B

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 91 kDa

종 반응성

human, rat, mouse

농도

~1 mg/mL

기술

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

phosphorylation (pTyr515)

유전자 정보

human ... NTRK2(4915)

일반 설명

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on human chromosome 9q21.32.

면역원

The antiserum was produced against synthesized peptide derived from human Trk B around the phosphorylation site of Tyr515.

Immunogen Range: 481-530

애플리케이션

Anti-phospho-Trk B (pTyr515) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

생화학적/생리학적 작용

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma.
Diamandis P, et al.
Diagnostic Pathology, 11(1), 13-13 (2016)
Micaela Lucarelli et al.
Molecular neurobiology, 60(9), 5395-5410 (2023-06-14)
Niemann-Pick type C1 (NPC1) disease is a lysosomal lipid storage disorder due to mutations in the NPC1 gene resulting in the accumulation of cholesterol within the endosomal/lysosomal compartments. The prominent feature of the disorder is the progressive Purkinje cell degeneration
A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects.
Spalek K, et al.
Translational Psychiatry, 6(3), e758-e758 (2017)
Stephanie M Muscat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(1), 155-172 (2022-11-18)
Perioperative neurocognitive disorders (PNDs) are characterized by confusion, difficulty with executive function, and episodic memory impairment in the hours to months following a surgical procedure. Postoperative cognitive dysfunction (POCD) represents such impairments that last beyond 30 d postsurgery and is
Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model
Iyer R, et al.
Cancer Letters, 372(2), 179-186 (2016)

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