T9691

Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL number: MFCD01092507
• UNSPSC 코드: 51111800
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous glycerol solution
• 분자량: antigen 140 kDa
• 종 반응성: rat, mouse, human
• 기술: immunocytochemistry: 1:100 using cultured cells; immunohistochemistry (frozen sections): 1:10; immunoprecipitation (IP): 1:250; western blot: 1:1,000 using NGF-treated PC12 cells
• UniProt 수납 번호: P04629
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr490)
• 유전자 정보: human ... NTRK1(4914) ; mouse ... Ntrk1(18211) ; rat ... Ntrk1(59109)

설명

일반 설명

TrkA belongs to the Trk proto-oncogene family and is expressed mainly in central and peripheral nervous systems. When TrkA binds to NGF, it autophosphorylates tyrosine residues like-Tyr⁴⁹⁰, Tyr⁶⁷⁴, Tyr⁶⁷⁵, Tyr⁷⁵¹, and Tyr⁷⁸⁵ and subsequently activates many downstream effector proteins. Defects in TrkA lead to congenital insensitivity to pain with anhidrosis. Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody can be used in immunocytochemistry (1:100, using cultured cells). It is also useful in identifying endogenous levels of phosphorylated Tyr⁴⁹⁰ in TrkA, TrkB and TrkC. Rabbit anti- phospho-TrkA (pTyr⁴⁹⁰) antibody is reactive in mouse, human and rat.

면역원

synthetic phosphopeptide Tyr⁴⁹⁰ corresponding to residues surrounding Tyr⁴⁹⁰ of human TrkA, conjugated to KLH. This sequence is highly conserved in TrkB and TrkC.

애플리케이션

Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody can be used in immunoprecipitation, immunoblotting and immunohistochemistry. It may also be used in western blotting when diluted to ratio of 1:1000 for NGF-treated PC12 cells.

물리적 형태

Solution in 10 mM sodium HEPES, pH 7.5, and 150 mM sodium chloride containing 100 μg/ml bovine serum albumin and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable