추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 33 kDa
종 반응성
rat, mouse, human
농도
~1 mg/mL
기술
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CCND1(595)
일반 설명
Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein.
The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3.
면역원
The antiserum was produced against synthesized peptide derived from human Cyclin D1.
Immunogen Range: 246-295
Immunogen Range: 246-295
애플리케이션
Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis.[1]
생화학적/생리학적 작용
CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.
Phan B
Oncotarget, 7(15), 19519-19530 (2016)
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Hui AB
Cancer Research, 65(18), 8125-8133 (2005)
The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.
Xie M
Medicine, 96(42), 1-9 (2017)
Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects.
Lanza C
Cell Cycle, 15(10), 1363-1375 (2016)
Chris Lanza et al.
Cell cycle (Georgetown, Tex.), 15(10), 1363-1375 (2016-04-14)
Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in
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