SAB4502581

Anti-Retinoic Acid Receptor β, C-Terminal antibody produced in rabbit

affinity isolated antibody

• 동의어(들): HBV-activated protein, RAR-β, RAR-ε, nuclear receptor 1B2, retinoic acid receptor β
• MDL number: MFCD00802879
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 50 kDa
• 종 반응성: mouse, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: P10826
• UniProt 수납 번호: P10826
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RARB(5915)

설명

일반 설명

Anti-Retinoic Acid Receptor β Antibody detects endogenous levels of total Retinoic Acid Receptor β protein.

Retinoic Acid Receptor β (RARB) is encoded by the gene mapped to human chromosome 3p24.2-p25. The encoded protein belongs to the nuclear receptor superfamily.

면역원

The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor beta.

Immunogen Range: 331-380

생화학적/생리학적 작용

Retinoic Acid Receptor β (RARB) interacts with its ligand retinoic acid (RA) and retinoid and plays a vital role in normal lung development. It is also involved in growth regulation of mammary epithelial cells. RARB acts as a tumor suppressor protein in various types of cancers, including thyroid carcinomas.
Mutation in the gene is associated with the development of anophthalmia and/or microphthalmia and diaphragmatic hernia. RARβ gene inactivation caused by RARβ methylation contributes to the pathogenesis of non-small cell lung cancer (NSCLC) and acts as a potential biomarker, risk factor and therapeutic target for NSLC.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable