SAB4502062
Anti-PAK1 antibody produced in rabbit
affinity isolated antibody
동의어(들):
α-PAK, PAK-1, Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, p65-PAK
로그인조직 및 계약 가격 보기
크기 선택
100 μG
₩677,107
₩677,107
예상 입고일2025년 8월 08일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
모든 사진(3)
크기 선택
보기 변경
100 μG
₩677,107
About This Item
₩677,107
예상 입고일2025년 8월 08일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 60 kDa
종 반응성
mouse, rat, human
농도
~1 mg/mL
기술
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... PAK1(5058)
일반 설명
Anti-PAK1 antibody detects endogenous levels of total PAK1 protein.
The PAK1 (p21 (RAC1) activated kinase 1) gene is mapped to human chromosome 11q13.5-q14.1. It belongs to the family of serine/threonine kinases and the gene is evolutionarily conserved.
면역원
The antiserum was produced against synthesized peptide derived from human PAK1.
Immunogen Range: 178-227
Immunogen Range: 178-227
생화학적/생리학적 작용
PAK1 (p21 (RAC1) activated kinase 1) maintains the cytoskeleton and cellular morphology. It is associated with cell cycle, cell motility, survival, and cell death. PAK1 is upregulated in different types of cancer. PAK1 is found to be involved in growth, invasion, and metastasis of cancer cells, as it affects the action of pro-apoptotic signals. In neurodegenerative diseases, such as Huntington′s disease and Alzheimer′s disease, and mental retardation, abnormal regulation of PAK1 is observed. PAK1 induces MAPK (mitogen activated protein kinase) signal pathway and cytoskeletal remodeling in breast cancer, thereby serving as an oncogene. PAK1 is known to significantly participate in the development, maturation and plasticity of the nervous system.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions.
Kumar A
Oncogene, 35(37), 4857-4865 (2016)
Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.
Fuchsova B
Neuroscience, 333, 331-344 (2016)
MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1.
Zhan MN
Cell Death & Disease, 8(1), 1-11 (2017)
Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons.
Kim H
Molecular Brain, 9(1):45, 1-13 (2016)
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma.
Schraml P
The American Journal of Pathology, 163(3), 985-992 (2003)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
