SAB4502021
Anti-NOTCH2 (Cleaved-Ala1734) antibody produced in rabbit
affinity isolated antibody
동의어(들):
Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor
로그인조직 및 계약 가격 보기
크기 선택
100 μG
₩677,107
₩677,107
예상 입고일2025년 6월 27일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
모든 사진(1)
크기 선택
보기 변경
100 μG
₩677,107
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
₩677,107
예상 입고일2025년 6월 27일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 79 kDa
종 반응성
rat, mouse, human
농도
~1 mg/mL
기술
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
proteolytically cleaved (Ala1734)
유전자 정보
human ... NOTCH2(4853)
일반 설명
The NOTCH2 (notch 2) gene is mapped to human chromosome 1p12. Anti-NOTCH2 (cleaved-Ala1734) antibody detects endogenous levels of fragment of activated NOTCH2 (cleaved-Ala1734) protein.
면역원
The antiserum was produced against synthesized peptide derived from human NOTCH2.
Immunogen Range: 1715-1764
Immunogen Range: 1715-1764
생화학적/생리학적 작용
The NOTCH2 (notch2) gene is known to be involved in the proliferation and cell cycle progression in cancer cells. Upregulation of the gene is observed in salivary adenoid cystic carcinoma, and hepatocellular carcinoma. Deletion of NOTCH2 offers tumor cells resistance to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development. The NOTCH2 gene is associated with the development of diabetic nephropathy.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
McDaniell R, et al.
American Journal of Human Genetics, 79(1), 169-173 (2006)
Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells
Wu WR, et al.
Oncology Reports, 36(1), 181-188 (2016)
Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients
Sharaf SA, et al.
Diabetes Research and Clinical Practice, 140, 304-313 (2018)
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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