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Merck
모든 사진(2)

문서

SAB4501587

Sigma-Aldrich

Anti-Integrin β3 antibody produced in rabbit

affinity isolated antibody

동의어(들):

CD61, GP3A, GPIIIa, ITB3, integrin β-3

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 87 kDa

종 반응성

human, mouse, rat

농도

~1 mg/mL

기술

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ITGB3(3690)

일반 설명

Anti-Integrin β3 Antibody detects endogenous levels of total Integrin β3 protein.

ITGB3 (integrin subunit β 3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.

면역원

The antiserum was produced against synthesized peptide derived from human Integrin beta3.

Immunogen Range: 739-788

생화학적/생리학적 작용

Mutations in ITGB3 (integrin subunit β 3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells promoted by reactive oxygen species.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells
Lei Y, et al.
Molecular and Cellular Proteomics, 10(10) (2011)
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models
Nurden AT, et al.
Blood, 118(23), 5996-6005 (2011)
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
Ghevaert C, et al.
Blood, 111(7), 3407-3414 (2008)

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