MAB2637

Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1

clone HMb3-1, from hamster(Armenian)

• 동의어(들): CD61 antigen, Platelet membrane glycoprotein IIIa, integrin beta chain, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), platelet glycoprotein IIIa, GPIIIa
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: hamster (Armenian)
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: HMb3-1, monoclonal
• 종 반응성: mouse
• 기술: flow cytometry: suitable; immunohistochemistry: suitable
• 동형: IgG
• NCBI 수납 번호: NP_058060.2
• UniProt 수납 번호: O54890
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Itgb3(16416)

설명

일반 설명

The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.

Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.

특이성

The antibody recognizes Integrin beta-3.

면역원

Recombinant protein corresponding to mouse Integrin beta-3.

애플리케이션

Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH.

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Piali, 1995).

품질

Evaluated by Flow Cytometry on mouse bone marrow-derived cells.

Flow Cytometry Analysis: 0.1-1 µg/mL of the antibody detected Integrin beta-3 on mouse bone marrow-derived cells

표적 설명

~ 86-87 kDa

물리적 형태

Format: Purified

분석 메모

Control
Mouse bone marrow-derived cells

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable