SAB4501319
Anti-GRM2 antibody produced in rabbit
affinity isolated antibody
동의어(들):
GPRC1B, GRM2, MGLUR2, Metabotropic glutamate receptor 2, mGluR2
로그인조직 및 계약 가격 보기
크기 선택
100 μG
₩775,968
₩775,968
예상 입고일2025년 6월 18일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
모든 사진(2)
크기 선택
보기 변경
100 μG
₩775,968
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
₩775,968
예상 입고일2025년 6월 18일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 95 kDa
종 반응성
rat, human, mouse
농도
~1 mg/mL
기술
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... GRM2(2912)
일반 설명
Anti-GRM2 Antibody detects endogenous levels of total GRM2 protein.
Metabotropic glutamate receptor 2 (MGLUR2/GRM2) with 872 amino acids, is encoded by the gene mapped to human chromosome 3. GRM2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. GRM2 is characterized with an α-helical helix 8 (H8) domain.
면역원
The antiserum was produced against synthesized peptide derived from human GRM2.
Immunogen Range: 241-290
Immunogen Range: 241-290
생화학적/생리학적 작용
Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. GRM2 signaling inhibits adenylyl cyclase (AC) activity. GRM2 is required for the modulation of synaptic transmission.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.
Ohishi H, et al.
Neuroscience, 53(4), 1009-1018 (1993)
Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR.
Bruno A, et al.
PLoS ONE, 7(8), e42023-e42023 (2012)
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
El Moustaine D, et al.
Proceedings of the National Academy of Sciences of the USA, 109(40), 16342-16347 (2012)
P J Flor et al.
The European journal of neuroscience, 7(4), 622-629 (1995-04-01)
A cDNA encoding the human metabotropic glutamate receptor type 2 (hmGluR2) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR2 probes. The deduced amino acid sequence of the human mGluR2 receptor consists of 872 residues and shows
A Farinha et al.
British journal of pharmacology, 172(9), 2383-2396 (2015-01-13)
The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tuned potentiation of these
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