Anti-GATA3 antibody detects endogenous levels of total GATA3 protein.
GATA-3 (GATA binding protein 3) is a T-cell transcription factor. It is highly expressed in fetal and adult thymus. It is located on human chromosome 10p14.
면역원
The antiserum was produced against synthesized peptide derived from human GATA3.
Immunogen Range: 274-323
생화학적/생리학적 작용
GATA-3 (GATA binding protein 3) plays an important role in the growth of T-cell neoplasms and early growth of T-cells. It acts as a specific marker in breast and urothelial carcinomas. GATA3 also acts as an immunophenotypic marker of acute leukemias.
특징 및 장점
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물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Enciso-Mora V, et al.
Nature Genetics (2010)
Characterisation of GATA3 expression in invasive breast cancer: differences in histological subtypes and immunohistochemically defined molecular subtypes
Shaoxian T, et al.
Journal of Clinical Pathology (2017)
T-cell transcription factor GATA-3 is an immunophenotypic marker of acute leukemias with T-cell differentiation
Dorfman DM, et al.
Human Pathology, 65, 166-174 (2017)
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