Anti-Collagen XII α1 Antibody detects endogenous levels of total Collagen XII α1 protein.
Collagen XII α1 belongs to the FACIT collagens (fibril-associated collagens with interrupted triple helices) family. It codes for the alpha chain of type XII collagen. It is located on human chromosome 6q13.
면역원
The antiserum was produced against synthesized peptide derived from human Collagen XII alpha1.
Immunogen Range: 1481-1530
애플리케이션
Anti-Collagen XII α1 antibody has been used in immunohistochemistry.[1]
생화학적/생리학적 작용
Collagen XII α1 participates in a benign bone tumor, subungual exostosis. Collagen XII organize the collagen fibrils and thereby preserves the bone and muscle integrity. Mutations in collagen XII results in Ehlers–Danlos/myopathy overlap syndrome.
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물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(11), 1499-1506 (2009-08-04)
Chondromyxoid fibroma, a rare benign bone tumor, may be mistaken for chondrosarcoma. Although cytogenetic studies of chondromyxoid fibroma are few, rearrangements of the long arm of chromosome 6, frequently expressed as an inv(6)(p25q13), are prominent. In this study, conventional cytogenetic
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