SAB4301248

Anti-phospho-Pim-1 (pTyr³⁰⁹) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): EC 2.7.11.1, PIM-1, Proto-oncogene serine/threonine-protein kinase pim-1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: 45 kDa
• 종 반응성: mouse, rat, human
• 농도: 1.0 mg/mL
• 기술: western blot: 1:500-1:1000 (Cell Lysate)
• 동형: IgG
• 수납 번호(accession number): NP_001230115.1
• UniProt 수납 번호: P11309
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr309)
• 유전자 정보: human ... PIM1(5292)

설명

일반 설명

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) is expressed at high levels in bone marrow, thymus, spleen, fetal liver, hippocampus, oral epithelium, and the prostate gland. PIM1 gene has five introns and six exons and is mapped to human chromosome 6p21.2.

특이성

The antibody detects endogenous levels of Pim-1 only when phosphorylated at tyrosine 309.

면역원

Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.

생화학적/생리학적 작용

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) modulates cell cycle progression, cellular division, differentiation, and apoptosis. It participates in genomic instability. PIM1 serves as an oncogenic survival factor. PIM1 gene is overexpressed in gastric carcinoma, squamous cell carcinoma, colorectal carcinoma, liver carcinoma, liposarcoma, and bladder cancer.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable