생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
rat, human, mouse
농도
0.7 mg/mL
기술
immunohistochemistry: 1:25- 1:100
동형
IgG
수납 번호(accession number)
NP_003344.1
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... UCN(7349)
일반 설명
Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.
특이성
The antibody detects endogenous levels of total UCN protein.
면역원
Synthetic peptide corresponding to residues near the C terminal of human urocortin
애플리케이션
Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.
생화학적/생리학적 작용
Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway
Schulman D, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 52(4), H1481-H1488 (2002)
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
Koob GF and Heinrichs SC
Brain Research, 848(1-2), 141-152 (1999)
Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors
Singh LK, et al.
Journal of Pharmacology and Experimental Therapeutics, 288(3), 1349-1356 (1999)
W J Giardino et al.
Translational psychiatry, 7(1), e1021-e1021 (2017-02-01)
Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway
Brar BK, et al.
The Journal of Biological Chemistry, 275(12), 8508-8514 (2000)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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