SAB4300659

Anti-CD10 antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-CALLA, Anti-MGC126681, Anti-MME, Anti-NEP, Anti-SFE
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: ~100 kDa
• 종 반응성: human, rat, mouse
• 농도: 1 mg/mL
• 기술: western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (S-Q-M-D-I)
• NCBI 수납 번호: NM_000902.3
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CD10(4311)

설명

일반 설명

Cluster of differentiation 10 (CD10) is also known as neprilysin (NEP), that is encoded by MME (membrane metallo-endopeptidase) gene. It has 24 exons and is located on chromosome 3q25.1 to q25.2. It is predominantly expressed in kidney. The protein is made of 742 amino acids with molecular weight of nearly 85 to 110kDa.

The antibody detects endogenous level of total CD10 protein.

면역원

Peptide sequence around aa. 6-10 (S-Q-M-D-I), according to the protein NP_000893.2

생화학적/생리학적 작용

Cluster of differentiation 10 (CD10) plays an important role in the degeneration of neuropeptides. It participates in several renal diseases. It plays a major role in Alzheimer′s disease. It helps in the degradation of β‐amyloid (Aβ) in the central nervous system (CNS).

특징 및 장점

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표적 설명

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable