Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein found in the astrocytes of CNS (central nervous system).{56,59} It is located on chromosome 17q21.
The antibody detects endogenous level of total GFAP protein.
면역원
Peptide sequence around aa. 423-427 (E-S-K-Q-E), according to the protein NP_002046.1
생화학적/생리학적 작용
Glial fibrillary acidic protein (GFAP) regulates intermediate filament network dynamics, cell morphology and focal adhesions. It helps in maintaining myelination and stability of CNS (central nervous system) white matter architecture.
특징 및 장점
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표적 설명
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
물리적 형태
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
면책조항
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(4), 1535-1559 (2018-10-31)
Neurotoxic A1 astrocytes are induced by inflammation after spinal cord injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be related to A1-astrocyte activation. Mesenchymal stem cell (MSC) transplantation is a promising therapy for SCI, where transplanted
GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination
Liedtke W, et al.
Neuron (1996)
GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions
Journal of neuroinflammation, 18(1), 256-256 (2021-11-07)
Neurotoxic microglia and astrocytes begin to activate and participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage and affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation