SAB4300490

Anti-BRCA1 (Ab-1423) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
• MDL number: MFCD01092286
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~220 kDa
• 종 반응성: human
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (H-G-S-Q-P)
• NCBI 수납 번호: NP_009225.1
• UniProt 수납 번호: P38398
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... BRCA1(672)

설명

일반 설명

BRCA1 (breast cancer 1) is a tumor suppressor gene, that is located on human chromosome 17q21. It has an N-terminal RING (really interesting new gene) domain, a negatively charged region in its C terminus, and C-terminal sequences partially homologous to yeast RAD9.

면역원

Peptide sequence around aa. 1421-1425 (H-G-S-Q-P), according to the protein BRCA1.

생화학적/생리학적 작용

BRCA1 (breast cancer 1) mutation carriers are expected to get breast and ovarian cancer. It is involved in several cellular processes like transcription regulation, DNA damage repair and protein ubiquitination. Interaction of BRCA1 with PABP1 (poly(A)-binding protein 1) helps to control protein synthesis.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

표적 설명

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable