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Merck
모든 사진(2)

주요 문서

SAB4200827

Sigma-Aldrich

Anti- Staphylococcal alpha-Toxin-Peroxidase antibody produced in rabbit

IgG fraction of antiserum

동의어(들):

Alpha-hemolysin (hly)

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About This Item

UNSPSC 코드:
12352203

결합

peroxidase conjugate

항체 형태

IgG fraction of antiserum

항체 생산 유형

primary antibodies

클론

polyclonal

설명

Research area: Microbiome

양식

lyophilized powder

분자량

~33 kDa

종 반응성

Staphylococcus aureus (alpha-Toxin (a-Hemolysin) )

농도

~4 mg/mL

기술

direct ELISA: 1:2,000-1:4,000 using 1 μg/mL Staphylococcal alpha-Toxin (a-Hemolysin) for coating.

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

Staphylococcus aureus subsp. aureus NCTC 8325 ... SAOUHSC_01121(3920722)

일반 설명

Staphylococcal alpha-Toxin is a pore forming cytotoxin. Native alpha toxin is a water-soluble monomer but later on gets converted to β-barrel in the host membranes. It is 34 kDa protein. The N- terminal and the C-terminal are involved in forming a membrane-binding epitope and the central domain forms a membrane-inserting, pore forming domain.

특이성

Anti-Staphylococcal alpha-Toxin-peroxidase antibody specifically recognizes Staphylococcal alpha-Toxin (?-Hemolysin) and has no cross reactivity with Staphylococcal Enterotoxin A (SEA), Cholera Toxin or Pseudomonas Exotoxin A

면역원

purified toxin from Staphylococcus aureus

애플리케이션

The antibody may be used in various immunochemical techniques including ELISA

생화학적/생리학적 작용

Staphylococcal alpha-Toxin plays a role in binding to the host membrane. At higher concentrations it makes the cells which are devoid of receptors to become more permeable and hence also to protein-free lipid bilayers.

진단 영향

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

물리적 형태

Supplied as a lyophilized powder.

저장 및 안정성

Store the lyophilized product at 2–8 °C. For extended storage after reconstitution, keep at –20 °C in working aliquots. Avoid repeated freeze-thaw cycles. For continuous use after reconstitution, keep at 2–8 °C for up to 1 month. Solutions at working dilution should be discarded if not used within 12 hours.

면책조항

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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Lot/Batch Number

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문서 라이브러리 방문

Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins
Bhakdi S, et al.
Archives of Microbiology, 165(2), 73-79 (1996)
Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury
Wilke GA and Wardenburg JB
Proceedings of the National Academy of Sciences of the USA, 107(30), 13473-13478 (2010)

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