생물학적 소스
rabbit
결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~55 kDa
종 반응성
human
향상된 검증
recombinant expression
Learn more about Antibody Enhanced Validation
기술
indirect immunofluorescence: 1:10,000-1:20,000 using HEK-293T cells overexpressing human dystrobrevin-a variant 6
western blot: 1:5,000-1:10,000 using lysates of HEK-293T cells overexpressing human dystrobrevin-a variant 6
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... DTNA(1837)
일반 설명
Dystrobrevin-α (α-DB or DTNA) belongs to the dystrobrevin (DB) subfamily of the dystrophin-related-protein family.α-DB is a component of the dystrophin-glycoprotein complex (DGC) that is located at the muscle sarcolemma and forms a transmembrane link between the cytoskeleton and the basal lamina. The DB family includes two isoforms α- and β-DB encoded by the different genes. α-DB is also abundantly expressed in developing neurons and in the adult central nervous system (CNS). The DTNA gene is located on the human chromosome at 18q12.1.
특이성
Anti-Dystrobrevin-α specifically recognizes human dystrobrevin-α.
면역원
synthetic peptide corresponding to a sequence at the C-terminal region of human dystrobrevin-a (DTNA), conjugated to KLH
애플리케이션
Anti-Dystrobrevin-α antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
생화학적/생리학적 작용
Dystrobrevin- α (α -DB) is involved in the formation and stability of synapses and the clustering of nicotinic acetylcholine receptors. Mutations in the DTNA gene are associated with congenital heart defects. Dystrobrevin is markedly reduced or absent in the sarcolemma of patients with Duchenne muscular dystrophy (DMD).
물리적 형태
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
저장 및 안정성
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
면책조항
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Prenatal diagnosis of de novo interstitial deletions involving 5q23. 1-q23. 3 and 18q12. 1-q12. 3 by array CGH using uncultured amniocytes in a pregnancy with fetal interrupted aortic arch and atrial septal defect
Chen C P, et al.
Gene, 531(2), 496-501 (2013)
Function and genetics of dystrophin and dystrophin-related proteins in muscle
Blake D J, et al.
Physiological Reviews (2002)
Dystrobrevins in muscle and non-muscle tissues
Rees M L J, et al.
Neuromuscular Disorders, 17(2), 123-134 (2007)
Dystrobrevin deficiency at the sarcolemma of patients with muscular dystrophy
Metzinger L, et al.
Human Molecular Genetics, 6(7), 1185-1191 (1997)
T Haenggi et al.
Cellular and molecular life sciences : CMLS, 63(14), 1614-1631 (2006-05-20)
The dystrophin glycoprotein complex (DGC) is a multimeric protein assembly associated with either the X-linked cytoskeletal protein dystrophin or its autosomal homologue utrophin. In striated muscle cells, the DGC links the extracellular matrix to the actin cytoskeleton and mediates three
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