SAB4200380

Anti-LAYN antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 동의어(들): Anti-LAYN antibody produced in rabbit, Anti-Layilin
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~43 kDa
• 종 반응성: human
• 농도: ~1.0 mg/mL
• 기술: indirect immunofluorescence: 2.5-5.0 μg/mL using human A549 cells.; western blot: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human LAYN.
• UniProt 수납 번호: Q6UX15
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... LAYN(143903)

설명

일반 설명

Layilin (LAYN) is a cell surface hyaluronan receptor, originally identified as a binding partner of talin located in membrane ruffles of spreading cells. LAYN is widely expressed in different cell lines and tissues. This gene is mapped to human chromosome 11q.

면역원

synthetic peptide corresponding to an internal region of human LAYN, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.

애플리케이션

Anti-LAYN antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

생화학적/생리학적 작용

Layilin (LAYN) binds to hyaluronan, a ubiquitous extracellular matrix component involved in the invasion of a variety of tumour cells, through its extracellular domain and to cytoskeleton-membrane linker proteins including Merlin and Radixin, through its cytoplasmic domain, implicating LAYN in cell adhesion and motility. LAYN is overexpressed in the human lung carcinoma A549. LAYN down-regulation by RNA interference, inhibits invasion and lymphatic metastasis of A549 cells.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable