결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~15 kDa
종 반응성
rat, human, mouse
기술
western blot: 1:1000-1:2000 using NIH3T3 or HeLa cell lysates
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
acetylation (Lys56)
유전자 정보
human ... HIST3H3(8290)
일반 설명
Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).
면역원
synthetic peptide containing acetylated Lys56 of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.
애플리케이션
Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.[1]
생화학적/생리학적 작용
Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Xie W, et al.
Molecular Cell, 33(4), 417-427 (2009)
A solitary human H3 histone gene on chromosome 1
Albig W, et al.
Human Genetics, 97(4), 486-491 (1996)
Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae
Azad GK, et al.
PLoS ONE, 8(3), e59003-e59003 (2013)
Shraddha Chauhan et al.
Environmental science and pollution research international, 31(20), 30149-30162 (2024-04-11)
Nanoparticles, particularly magnesium oxide nanoparticles (MgO-NPs), are increasingly utilized in various fields, yet their potential impact on cellular systems remains a topic of concern. This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae
Histone Variants: Signaling or Structural Modules
Handbook of Cell Signaling, 2409-2425 (2010)
활성 필터
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