추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 225 kDa (rat)
antigen ~150 kDa (Human)
종 반응성
rat, chicken, human
향상된 검증
recombinant expression
Learn more about Antibody Enhanced Validation
농도
~1.5 mg/mL
기술
indirect immunofluorescence: 2-4 μg/mL using chicken embryo fibroblast cells
western blot: 1-2 μg/mL using HEK-293T cell lysates overexpressing human tensin1
western blot: 1.5-3.0 μg/mL using lysates of A10 cells
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TNS1(7145)
rat ... Tns1(301509)
일반 설명
Tensins are a new family of focal adhesion proteins that link between the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin1-4, encoded by different genes. Tensins are multidomain proteins consisting of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and PTB domains. Tensin 1 (also known as TNS1), shares extensive homology with tensin 2 and tensin 3 at its N- and C-terminal regions. Tensin 1 mRNA is broadly expressed in mouse embryo and various human tissues and is localized to focal adhesions.
면역원
synthetic peptide corresponding to a sequence located near the C-terminus of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.
애플리케이션
Anti-Tensin 1 (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
생화학적/생리학적 작용
Tensin 1 plays an important role in regulating cell polarization, shape, motility and invasion. Tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Regulation of tensin-promoted cell migration by its focal adhesion localization and the SH2 domain
Chen H and Lo SH
The Biochemical Journal, 370, 1039-1045 (2003)
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin
Hafizi S, et al.
Biochemical and biophysical research communications, 299(5), 793-800 (2002)
Alexandra Woychek et al.
Cytoskeleton (Hoboken, N.J.), 76(2), 200-208 (2019-01-23)
The nuclear envelope protein nesprin-2G is a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is responsible for mechanical and signaling crosstalk between the nucleus and cytoskeleton. A prior study has demonstrated that nesprin-2G knockout mice show
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
Chen H, et al.
Proceedings of the National Academy of Sciences of the USA, 99(2), 733-738 (2002)
Alexandra Woychek et al.
Cytoskeleton (Hoboken, N.J.), 76(2), 200-208 (2019-01-23)
The nuclear envelope protein nesprin-2G is a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is responsible for mechanical and signaling crosstalk between the nucleus and cytoskeleton. A prior study has demonstrated that nesprin-2G knockout mice show
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