생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~50 kDa
종 반응성
human
포장
antibody small pack of 25 μL
농도
~1 mg/mL
기술
western blot: 1-2 μg/mL using whole extracts of human U87 cells
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ULK3(25989)
일반 설명
Anti-ULK3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human ULK3, conjugated to KLH. Unc-51-like kinase 3 (ULK3) belongs to the ULK family of serine/threonine kinases. ULK3 is an autophagy related protein with an N-terminal kinase domain, which shows high similarity to those of ULK1 and ULK2. ULK3 localizes to the elongating isolation membrane upon autophagy activation.
애플리케이션
Anti-ULK3 antibody produced in rabbit has been used in immunoblotting.
생화학적/생리학적 작용
Unc-51-like kinase 3 (ULK3) controls abscission timing in response to lagging chromosomes. Overexpression of ULK3 induces autophagy and senescence. ULK3 is also a positive regulator of the Hedgehog signalling pathway.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
mTOR regulation of autophagy
Jung CH, et al.
Febs Letters, 584(7), 1287-1295 (2010)
The ULK1 complex: sensing nutrient signals for autophagy activation
Wong PM, et al.
Autophagy, 9(2), 124-137 (2013)
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
Sulli G, et al.
Nature, 553(7688), 351-351 (2018)
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI
Goruppi , et al.
Testing, 20(10), 2468-2479 (2017)
Gabriele Sulli et al.
Nature, 553(7688), 351-355 (2018-01-11)
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation
활성 필터
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