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Merck
모든 사진(1)

주요 문서

SAB4200108

Sigma-Aldrich

Anti-TIN2 antibody, Mouse monoclonal

clone TIN30, purified from hybridoma cell culture

동의어(들):

Anti-TERF1 (TRF1)-interacting nuclear factor 2, Anti-TIN2L, Anti-TINF2

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크기 선택

200 μL
₩729,278

₩729,278


예상 입고일2025년 3월 12일세부사항


벌크 견적 요청

크기 선택

보기 변경
200 μL
₩729,278

About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

₩729,278


예상 입고일2025년 3월 12일세부사항


벌크 견적 요청

생물학적 소스

mouse

Quality Level

결합

unconjugated

항체 형태

purified from hybridoma cell culture

항체 생산 유형

primary antibodies

클론

TIN30, monoclonal

양식

buffered aqueous solution

분자량

antigen ~40 kDa

종 반응성

human

포장

antibody small pack of 25 μL

농도

~1.0 mg/mL

기술

western blot: 0.5-1.0 μg/mL using HeLa cell extract

동형

IgG1

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... TINF2(26277)

일반 설명

Monoclonal Anti-TIN2 (mouse IgG1 isotype) is derived from the hybridoma TIN-30 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human TIN-2, conjugated to keyhole limpet hemocyanin (KLH). The six shelterin subunits are: TRF1, TRF2, and POT1 which directly recognize the TTAGGG repeats, and TIN2, Rap1 and TPP1. TIN2 (TRF-1 interacting nuclear factor 2) is recruited to the telomere through the TRF homology (TRFH) domain of TRF1 and tethers TPP1/POT1 to TRF1 and TRF2.

애플리케이션

Monoclonal Anti-TIN2 antibody produced in mouse has been used in immunoblotting.

생화학적/생리학적 작용

TIN2 (TRF-1 interacting nuclear factor 2) also connects TRF1 to TRF2 and this link contributes to the stabilization of TRF2 on telomeres. In addition, TIN2 has also been found to tether the telomeres to the nuclear matrix. Interestingly, this protein has also been found to be mutated in Dyskeratosis Congenita, a multi-system disorder which in its classical form is characterized by abnormalities of the skin, nails, and mucous membranes.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres
Ye JZS, et al.
The Journal of Biological Chemistry, 279(45), 47264-47271 (2004)
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix
Kaminker PG, et al.
Cell Cycle, 8(6), 931-939 (2009)
Titia de Lange
Genes & development, 19(18), 2100-2110 (2005-09-17)
Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific proteins associates with this sequence and protects chromosome ends. By analogy to other chromosomal protein complexes such as condensin and cohesin
David Frescas et al.
Genes & development, 28(2), 153-166 (2014-01-23)
The progressive bone marrow failure syndrome dyskeratosis congenita (DC) is often caused by mutations in telomerase or the factors involved in telomerase biogenesis and trafficking. However, a subset of DC patients is heterozygous for mutations in the shelterin component TIN2.

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