추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~95 kDa
향상된 검증
recombinant expression
Learn more about Antibody Enhanced Validation
농도
~1.5 mg/mL
기술
immunoprecipitation (IP): 2.5-5 μg using HEK-293T cell lysate overexpressing human DVL3
western blot: 0.25-0.5 μg/mL using HEK-293T cell lysates overexpressing human DVL3
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... DVL3(1857)
일반 설명
Dishevelled 3 (DVL3) is a phosphoprotein rich in serine and threonine. It is widely expressed in fetal tissues and specifically expressed in various adult tissues. DVL3 gene is mapped to human chromosome 3q27.1
특이성
Anti-DVL3 (N-terminal) specifically recognizes human DVL3.
애플리케이션
Anti-DVL3 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
생화학적/생리학적 작용
Dishevelled 3 (DVL3) participates in the wingless-related integration site (Wnt) signaling pathway. It plays a key role in hippocampal neurogenesis regulation. Knockdown of DVL3 has been shown to attenuate the activation of the wnt signaling pathway by Wnt3A. DVL3 functions in redundant pathways with DVL1 and DVL2, and is necessary in normal cardiac, cochlea, and neural tube development in mice. DVL3, like other members of the DVL family, functions upstream of glycogen synthase kinase-3 (GSK3) to modulate the canonical wnt pathway. A frame shift mutation in DVL3 gene is implicated in Robinow syndrome. Allelic variation in the DVL3 gene may be associated with major depressive disorder.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
저장 및 안정성
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
Etheridge SL, et al.
PLoS Genetics, 4(11), e1000259-e1000259 (2008)
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs
Hanakova K, et al.
Cell communication and signaling : CCS, 17(1), 170-170 (2019)
Integrating expression-related SNPs into genome-wide gene-and pathway-based analyses identified novel lung cancer susceptibility genes
Wang Y, et al.
International journal of cancer management, 142(8), 1602-1610 (2018)
DVL3 alleles resulting in a- 1 frameshift of the last exon mediate autosomal-dominant Robinow syndrome
White JJ, et al.
American Journal of Human Genetics, 98(3), 553-561 (2016)
The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3
Sutton LP and Rushlow WJ
The International Journal of Neuropsychopharmacology, 15(7), 965-979 (2012)
활성 필터
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