₩816,060
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추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
mouse, human
기술
ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 500-3000
NCBI 수납 번호
UniProt 수납 번호
응용 분야
research pathology
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... GPC1(2817)
일반 설명
Glypican 1 (GPC1) is located at 2q37.3 on the human chromosome.[1] It belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. GPC1 is localized in the vascular system.[2] GPC1 consists of an N-terminal secretory signal peptide, 14 conserved cysteine residues, a heparan sulfate (HS) attachment domain near the C terminus and a hydrophobic domain for attachment of the glycosylphosphatidylinositol (GPI) at the C terminus.[3]
면역원
Recombinant protein encompassing a sequence within the center region of human Glypican 1.
애플리케이션
생화학적/생리학적 작용
Glypican 1 (GPC1) plays an important role in cell growth, differentiation and morphogenesis.[2][6] It also plays a role in cell migration, adhesion, anti-coagulation, lipoprotein metabolism and modulation of growth factors. GPC1 exhibits chaperone-like activity by restoring the binding activity of oxidized VEGF165 (vascular endothelial growth factors-165).[2] Overexpression of GPC1 results in over accumulation of β-amyloid protein (Aβ) in the Alzheimer′s disease (AD) brain.[7] Mutation in this gene is associated with Niemann-Pick C1 disease.[8]
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Glypican-1 as an Abeta binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer?s disease
Watanabe N, et al.
Faseb Journal, 18(9), 1013-1015 (2004)
Characterization of Slit protein interactions with glypican-1
Ronca F, et al.
Test, 276(31), 29141-29147 (2001)
Molecular delineation of deletions on 2q37. 3 in three cases with an Albright hereditary osteodystrophy-like phenotype
Shrimpton A E, et al.
Clinical Genetics, 66(6), 537-544 (2004)
Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
Gengrinovitch S, et al.
Test, 274(16), 10816-10822 (1999)
Beth A Helmink et al.
Nature, 577(7791), 549-555 (2020-01-17)
Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers1-10 and strategies to augment clinical response have largely focused on the T cell compartment. However, other immune subsets may also contribute to anti-tumour immunity11-15, although these
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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