SAB1408617

Anti-PFKFB1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• 동의어(들): F6PK, HL2K, MGC116715, MGC116717, PFRX
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~54.7 kDa
• 종 반응성: human
• 기술: immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI 수납 번호: NM_002625.1
• UniProt 수납 번호: P16118
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PFKFB1(5207)

설명

일반 설명

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) is encoded by the gene mapped to human chromosome Xp11.21. The encoded protein is one among the four isoenzymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. PFKFB1 is expressed predominantly in liver.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. (provided by RefSeq)

면역원

PFKFB1 (NP_002616.1, 1 a.a. ~ 471 a.a) full-length human protein.

Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

애플리케이션

Anti-PFKFB1 antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate. It plays a vital role in regulation of both glycolysis and gluconeogenesis. PFKFB1 also facilitates cell growth and apoptosis.

물리적 형태

Solution in phosphate buffered saline, pH 7.4

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable