SAB1306388

ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 동의어(들): ACVR1, ACVRLK2, Activin receptor type I, Activin receptor type-1, Activin receptor-like kinase 2
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: 57153 Da
• 종 반응성: human, mouse
• 기술: immunohistochemistry: 1:50-1:100; western blot: 1:1000
• NCBI 수납 번호: NP_001096.1
• UniProt 수납 번호: Q04771
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ACVR1(90)

설명

일반 설명

Activin A receptor type 1 (ACVR1) gene encodes a transmembrane protein that belongs to the bone morphogenetic protein (BMP) type I receptors subfamily of the transforming growth factor-β (TGF-β) receptors. ACVR1 is a single-pass type I membrane protein with a ligand-binding extracellular domain, a transmembrane domain, and a cytoplasmic domain. ACVR1 gene is expressed abundantly in endothelial cells, parenchymal cells, fibroblasts, and tumor-derived epithelial cells. This gene is located on human chromosome 2q24.1.

애플리케이션

Anti-Activin receptor type IA (ACVR1) (CENTER R147) antibody produced in rabbit has been used in immunohistochemistry (1:100) and western blot (1:100).

생화학적/생리학적 작용

Activin A receptor type 1 (ACVR1) protein can bind activin in concert with activin receptor type 2 (ActRII) or activin receptor type-2B (ActRIIB). It participates in activin signaling. It is also capable of forming a complex with either the bone morphogenetic protein (BMP)-2/7-bound bone morphogenetic protein receptor type II (BMPR-II) or activin A receptor type 2A/2B (ACVR2A/ACVR2B). Somatic mutations of the ACVR1 gene are associated with primary ovary and colon cancer. It is considered a target gene to fibrodysplasia ossificans progressiva (FOP).

물리적 형태

Supplied in PBS with 0.09% (W/V) sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable