S9882
Sulfachloropyridazine
동의어(들):
4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide, N1-(6-Chloro-3-pyridazinyl)sulfanilamide
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C10H9ClN4O2S
CAS Number:
Molecular Weight:
284.72
Beilstein:
261558
EC Number:
MDL number:
UNSPSC 코드:
51102829
PubChem Substance ID:
NACRES:
NA.85
추천 제품
양식
powder
색상
off-white to light yellow
solubility
0.5 M NaOH: soluble 50 mg/mL
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
동작 모드
DNA synthesis | interferes
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2
InChI
1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
InChI key
XOXHILFPRYWFOD-UHFFFAOYSA-N
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애플리케이션
생화학적/생리학적 작용
Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[3]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine[4].
기타 정보
Keep container tightly closed in a dry and well-ventilated place.
이미 열람한 고객
[Sulfachloropyridazine in the treatment of acute infections of the urinary tract in childhood].
R C PEDRINAZZI et al.
Minerva pediatrica, 12, 1342-1347 (1960-10-27)
Absorption and Excretion of Sulfachloropyridazine
Wilfred F. Jones, Jr, Mohsen Ziai, et al.
Exp. Biol. Med, 95, 642-645 (1957)
Paul A Blackwell et al.
Chemosphere, 67(2), 292-299 (2007-01-06)
The environmental fate of the antibiotics sulfachloropyridazine and oxytetracycline was investigated in a sandy loam soil. Liquid pig manure was fortified with the compounds and then applied to soil plots to investigate leaching, dissipation and surface run-off under field conditions.
Paul Kay et al.
Environmental toxicology and chemistry, 23(5), 1136-1144 (2004-06-08)
The environment may be exposed to veterinary medicines administered to livestock through the application of organic fertilizers to land. For other groups of substances that are applied to agricultural land (e.g., pesticides), preferential flow in underdrained clay soils has been
Thomas L ter Laak et al.
Environmental toxicology and chemistry, 25(4), 904-911 (2006-04-25)
Antimicrobial agents are the most heavily used pharmaceuticals in intensive husbandry. Their usual discharge pathway is application to agricultural land as constituents of animal manure, which is used as fertilizer. Many of these compounds undergo pH-dependent speciation and, therefore, might
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