S8826

Semax

≥98% (HPLC)

• 동의어(들): ACTH (4-7), Pro-Gly-Pro trifluoroacetate salt, L-Methionyl-L-a-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline trifluoroacetate salt, Met-Glu-His-Phe-Pro-Gly-Pro
• 실험식(Hill 표기법): C₃₇H₅₁N₉O₁₀S · xC₂HF₃O₂
• CAS Number: 80714-61-0
• Molecular Weight: 813.92 (free base basis)
• MDL number: MFCD04113563
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329824612
• NACRES: NA.32

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to tan
• solubility: H₂O: >2 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: OC(=O)C(F)(F)F.CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(O)=O
• InChI: 1S/C37H51N9O10S.C2HF3O2/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56;3-2(4,5)1(6)7/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56);(H,6,7)/t24-,25-,26-,27-,28-,29-;/m0./s1
• InChI key: UAXRUQRHZBYPHF-IGCYJKAMSA-N

설명

일반 설명

Semax regulates the expression and the activation of the hippocampal (brain-derived neurotrophic factor) BDNF/(tropomyosin receptor kinase B) trkB system. It enhances selective attention at the time of information reception, increases memory consolidation and stimulates learning abilities. Semax is an active element of SEMAX drugs, which is used for the treatment of brain hypoxia and ischemia. It stimulates the activity of choline acetyltransferase.[1] Semax exhibits properties of the melanocortin (MC) receptor antagonist.[2]

생화학적/생리학적 작용

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10). It activates the transcription of neurotrophins and has neuroprotective and nootropic activity.

Semax is a neuroprotective ACTH (4-10) analog.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable