S7198
Sivelestat sodium salt hydrate
≥98% (HPLC), solid
동의어(들):
EI 546 sodium salt hydrate, Elaspol sodium salt hydrate, LY 544349 sodium salt hydrate, Ono-5046 sodium salt hydrate, o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩170,723
25 MG
₩845,901
모든 사진(1)
크기 선택
보기 변경
5 MG
₩170,723
25 MG
₩845,901
About This Item
실험식(Hill 표기법):
C20H22N2O7S · xNa+ · yH2O
CAS Number:
Molecular Weight:
434.46 (anhydrous free acid basis)
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
solid
색상
white to off-white
solubility
DMSO: 10 mg/mL, clear
저장 온도
room temp
SMILES string
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key
BTGNGJJLZOIYID-UHFFFAOYSA-N
애플리케이션
Sivelestat sodium salt hydrate may be used to inhibit human neutrophil elastase-mediated cell signaling.
생화학적/생리학적 작용
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
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