S2075

Src Inhibitor-1

≥98% (HPLC)

• 동의어(들): 4-(4′-Phenoxyanilino)-6,7-dimethoxyquinazoline, 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, SKI-1, Src-l1
• 실험식(Hill 표기법): C₂₂H₁₉N₃O₃
• CAS Number: 179248-59-0
• Molecular Weight: 373.40
• MDL number: MFCD01815300
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824504
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white
• solubility: DMSO: >10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
• InChI: 1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
• InChI key: DMWVGXGXHPOEPT-UHFFFAOYSA-N

설명

애플리케이션

Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.

생화학적/생리학적 작용

Apart from Src kinase, some Src inhibitors also inhibit the activity of Abl kinase, Lck, Csk and Yes proteins and are therefore being explored as viable anti-cancer drug options.

Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC₅₀ = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC₅₀ = 0.32 μM and 30 μM, respectively).

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3