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Merck
모든 사진(1)

문서

S1384

Sigma-Aldrich

N-Succinyl-Ala-Ala-Val p-nitroanilide

elastase substrate

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C21H29N5O8
CAS Number:
61043-47-8
Molecular Weight:
479.48
EC Number:
262-569-3
MDL number:
MFCD00038473
UNSPSC 코드:
12352204
PubChem Substance ID:
24899476

분석

≥98% (TLC)

형태

powder

solubility

1 N NH4OH: 50 mg/mL, clear, yellow

저장 온도

2-8°C

SMILES string

CC(C)C(NC(=O)C(C)NC(=O)C(C)NC(=O)CCC(O)=O)C(=O)Nc1ccc(cc1)N(=O)=O

InChI

1S/C21H29N5O8/c1-11(2)18(21(32)24-14-5-7-15(8-6-14)26(33)34)25-20(31)13(4)23-19(30)12(3)22-16(27)9-10-17(28)29/h5-8,11-13,18H,9-10H2,1-4H3,(H,22,27)(H,23,30)(H,24,32)(H,25,31)(H,28,29)

InChI key

IFAOJWCXOQHSQT-UHFFFAOYSA-N

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기질

Substrate for human and rat leukocyte elastases

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

G D Virca et al.
European journal of biochemistry, 144(1), 1-9 (1984-10-01)
Rat is a likely test animal for determining the efficacy of proteinase inhibitor drugs directed toward human leukocyte elastase and cathepsin G. We therefore sought to assess and compare relevant properties of both human and rat leukocyte elastase and cathepsin
Rami A Al-Horani et al.
Molecules (Basel, Switzerland), 24(11) (2019-06-09)
Pentamidine is bis-oxybenzamidine-based antiprotozoal drug. The parenteral use of pentamidine appears to affect the processes of blood coagulation and/or fibrinolysis resulting in rare but potentially life-threatening blood clot formation. Pentamidine was also found to cause disseminated intravascular coagulation syndrome. To
H R Wenzel et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361(9), 1413-1416 (1980-09-01)
A simple synthesis is described for 3-carboxypropionyl-Ala-Ala-Val-4-nitroanilide, a convenient and very specific substrate for human leukocyte elastase (Km = 1.0mM, kcat = 8.7 s-1). The substrate does not undergo appreciable spontaneous hydrolysis. It is not cleaved by trypsin or chymotrypsin
Stein, R.L.,
Journal of the American Chemical Society, 105, 5111-5111 (1983)
Apparao B Kummarapurugu et al.
American journal of respiratory cell and molecular biology, 64(2), 260-267 (2020-12-03)
Cystic fibrosis (CF) lung disease is marked by high concentrations of neutrophil elastase (NE) and DNA polymers; both factors contribute to airway disease. Although inhaled recombinant human dornase alfa reduces the frequency of CF pulmonary exacerbations, it also increases free

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