S1141

Spermine tetrahydrochloride

BioReagent, for molecular biology

• 동의어(들): N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• 실험식(Hill 표기법): C₁₀H₂₆N₄ · 4HCl
• CAS Number: 306-67-2
• Molecular Weight: 348.18
• Beilstein: 3911771
• EC Number: 206-189-8
• MDL number: MFCD00012914
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24899462
• NACRES: NA.52

속성

• Grade: for molecular biology
• 제품 라인: BioReagent
• 형태: solid
• mp: 310-311 °C (dec.) (lit.)
• solubility: H₂O: soluble 100 mg/mL, clear, colorless to light yellow
• 외래 활성: DNase, RNase, protease, NICKase, none detected
• 저장 온도: room temp
• SMILES string: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• InChI key: XLDKUDAXZWHPFH-UHFFFAOYSA-N

설명

일반 설명

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

애플리케이션

Used to precipitate DNA from low salt aqueous buffers.

생화학적/생리학적 작용

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319
• 예방조치 성명서: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves