종 반응성
mouse, human
기술
ELISA: suitable
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/ml
배송 상태
wet ice
저장 온도
−20°C
일반 설명
The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1.[1] Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.[2]
This ELISA antibody pair detects mouse and human PAI-1.
애플리케이션
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
생화학적/생리학적 작용
PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity.[3] PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling.[4] Studies also also predict that stress and depression might influence PAI-1 expression.[5]
기타 정보
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
TGF-? induces p53/Smads complex formation in the PAI-1 promoter to activate transcription.
Kawarada Y, et al.
Scientific Reports, 6, 35483-35483 (2016)
Hyperglycaemia-induced reciprocal changes in miR-30c and PAI-1 expression in platelets.
Luo M, et al.
Scientific Reports, 6, 36687-36687 (2016)
Plasminogen activator inhibitor-1 in depression: results from animal and clinical studies.
Jiang H, et al.
Scientific Reports, 6, 30464-30464 (2016)
Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 366-366 (2006)
CpG methylation of the PAI-1 gene 5?-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines.
Gao S, et al.
Thrombosis and Haemostasis, 93(03), 651-660 (2005)
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