RAB1050

Human Galectin-8 ELISA Kit

for cell culture supernatants, plasma, and serum samples

• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: human
• 포장: kit of 96 wells (12 strips x 8 wells)
• 기술: ELISA: suitable
• 입력: sample type plasma; sample type serum sample(s); sample type cell culture supernatant(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.16 ng/ml
• 검출 방법: colorimetric
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... LGALS8(3964)

설명

일반 설명

This ELISA antibody pair detects Human Galectin-8 (LGALS8)

애플리케이션

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

생화학적/생리학적 작용

Galectin-8 (Gal-8) is a member of “tandem-repeat” galectin family, possesses two carbohydrate binding domains linked by a short peptide. The short peptide accounts for Gal-8 cell adhesion and downstream signalling.[1] Tumor cells, as well as normal tissues, express Gal-8.[2] The expression level of Gal-8 is higher in multiple myeloma conditions and enhances adhesion to vascular endothelium.[1] Galectin-8 binds to integrin selectively and inhibits cell adhesion and promotes apoptosis.[3] Gal-8 interacts with integrin alpha and regulates neutrophil adhesion to endothelial cells and migration.[2] Gal-8 ligand binds to cluster of differentiation 44 (CD44) and causes an inflammatory response in rheumatoid arthritis.[4] Overexpression of Gal-8 plays a key role in metastasis of prostate cancer and cell survival by causing rearrangement of the cytoskeleton and E-cadherin expression.[5]

기타 정보

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

안전성 정보

• 픽토그램: GHS05
• 신호어: Warning
• 유해 및 위험 성명서: H290
• 예방조치 성명서: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable