RAB0161

Phospho-EGFR (pSer¹⁰⁷⁰) ELISA Kit

for detection of human, mouse or rat phospho-egfr (pSer¹⁰⁷⁰) in cell and tissue lysates

• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: mouse, human, rat
• 기술: ELISA: suitable; capture ELISA: suitable
• 입력: sample type tissue lysate; sample type cell lysate
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... EGFR(1965)

설명

일반 설명

The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4.[1][2] EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.[3]

면역원

EGFR (pTyr¹⁰⁷⁰) synthetic phosphopeptide

애플리케이션

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

생화학적/생리학적 작용

The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy.[2] EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells.[1] EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF.[4] There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis.[1][4] Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.[5]

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H290,H335
• Hazard Classifications: Met. Corr. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials