추천 제품
분석
≥98% (HPLC)
양식
solid
solubility
DMSO: 16 mg/mL
주관자
Roche
저장 온도
2-8°C
SMILES string
CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C
InChI
1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3
InChI key
TUNMGCULOKMBNJ-UHFFFAOYSA-N
생화학적/생리학적 작용
Ro 4-1284 is a reversible VMAT2 inhibitor.
특징 및 장점
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
가장 최신 버전 중 하나를 선택하세요:
J E Leysen et al.
European journal of pharmacology, 206(1), 39-45 (1991-01-25)
[3H]Ketanserin was found to label (besides a low amount of 5-HT2 receptors) non-serotonergic binding sites on human platelet membranes. The latter binding was detected in the presence of excess of the 5-HT2 antagonist BW501, and was potently inhibited by tetrabenazine.
A M Dopico et al.
Journal of neurochemistry, 61(2), 481-489 (1993-08-01)
A single dose of x-irradiation was applied on the cephalic end of newborn rats, and the alterations in the noradrenergic afferents to the cerebellum were studied 180 days later. A net increase in the noradrenaline content of cerebellum was found
Innately hearing impaired Sprague-Dawley rats exhibit audiogenic seizure susceptibility following monoamine depletion.
C E Reigel et al.
Proceedings of the Western Pharmacology Society, 36, 267-271 (1993-01-01)
A Colzi et al.
The Journal of pharmacology and experimental therapeutics, 265(1), 103-111 (1993-04-01)
The effects of reversible inhibitors of monoamine oxidase-A (moclobemide, Ro 41-1049, both 20 mg/kg, i.p., and brofaromine, 10 mg/kg, i.p.) on the outflow of dopamine (DA) and its metabolites (3,4-dihydroxyphenylacetic acid and homovanillic acid) as well as of 5-hydroxyindoleacetic acid
C R Berry et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 37(12), 2011-2016 (1996-12-01)
Para-[18F]fluorobenzylguanidine ([18F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [18F]PFBG in perfused, isolated rat heart. Fluorine-18-PFBG was administered to working rat hearts within the perfusion medium at
활성 필터
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