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Key Documents

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R137

Sigma-Aldrich

Ro 31-0432

solid

동의어(들):

3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride, 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride, Bisindoylmaleimide XI

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About This Item

실험식(Hill 표기법):
C28H28N4O2 · HCl
CAS Number:
145333-02-4
Molecular Weight:
489.01
UNSPSC 코드:
12352200
PubChem Substance ID:
329824001
NACRES:
NA.77

생물학적 소스

synthetic (organic)

분석

≥98% (TLC)

형태

solid

저장 조건

protect from light

색상

orange

solubility

DMSO: 5 mg/mL
H2O: insoluble

저장 온도

−20°C

SMILES string

Cl.CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H

InChI key

HSPRASOZRZDELU-UHFFFAOYSA-N

생화학적/생리학적 작용

Protein kinase C (PKC) inhibitor; membrane-derived PKC inhibitor.

특징 및 장점

This compound is featured on the GRKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

S E Wilkinson et al.
The Biochemical journal, 294 ( Pt 2), 335-337 (1993-09-01)
The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha
Inhibition of PTH desensitization by inhibition of the G protein-coupled receptor kinase-5 enzyme with Ro 32-0432.
Moore, J.B., et al.
Faseb Journal, 12, A741-A741 (1998)
Yuchen Li et al.
Stem cell research & therapy, 11(1), 330-330 (2020-10-27)
We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. Additionally, miR-137 is reported to regulate ferroptosis and to be involved
Soo Jung Lee et al.
International journal of molecular sciences, 20(24) (2019-12-11)
MicroRNAs (miRNAs) can be used to target a variety of human malignancy by targeting their oncogenes or tumor suppressor genes. The developmental endothelial locus-1 (Del-1) might be under miRNA regulation. This study investigated microRNA-137 (miR-137) function and Del-1 expression in
D Gozal et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(2), 641-648 (1998-02-26)
Although protein kinase C (PKC) is an essential component of multiple neurally mediated events, its role in respiratory control remains undefined. The ventilatory effects of a systemically active PKC inhibitor (Ro-32-0432; 100 mg/kg i.p.) were assessed by whole body plethysmography
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