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R0395
Rapamycin
Rapamycin from Streptomyces hygroscopicus
from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor
동의어(들):
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
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모든 사진(3)
크기 선택
보기 변경
1 MG
₩709,790
About This Item
실험식(Hill 표기법):
C51H79NO13
CAS Number:
Molecular Weight:
914.17
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder
Quality Level
분석
≥95% (HPLC)
양식
powder
색상
off-white
solubility
ethanol: 2 mM
DMSO: soluble
항생제 활성 스펙트럼
fungi
yeast
동작 모드
enzyme | inhibits
protein synthesis | interferes
저장 온도
−20°C
SMILES string
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
유전자 정보
human ... FKBP1A(2280)
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일반 설명
Chemical structure: macrolide
Rapamycin is derived from Streptomyces hygroscopicus . It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.[1] It suppresses protein kinase C activity and enhances ion transport in A6 cells. It also suppresses the immune response in membrane and cytosolic preparations.[2] Additionally, it has specific effects on the translation of endogenous mRNAs and inhibits the translation of 5′TOP mRNAs by blocking p70s6k activation in the signaling pathway. Rapamycin exhibits antineoplastic properties.
애플리케이션
Rapamycin from Streptomyces hygroscopicus has been used:
- to treat BV2 cells or BV2-LC3 cells for autophagy assay[3]
- as an autophagy activator in the bone marrow mesenchymal stem cells (BM-MSCs) transfected with lentivirus carrier of small interfering RNA for FOXO3 (siFOXO3) to study the effects of Forkhead Box O3 (FOXO3) on the autophagy of BM-MSCs[4]
- to pre-incubate villi to inhibit the mammalian target of rapamycin complex 1 (mTORC1) signaling[5]
생화학적/생리학적 작용
A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
특징 및 장점
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
기타 정보
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Carc. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells
Rokaw MD, et al.
The Journal of Biological Chemistry, 271, 32468-32473 (1996)
FOXO3 is targeted by miR-223-3p and promotes osteogenic differentiation of bone marrow mesenchymal stem cells by enhancing autophagy
Long C, et al.
Human Cell : Official Journal of Human Cell Research Society (2021)
Activation of autophagy pathway suppresses the expression of iNOS, IL6 and cell death of LPS-stimulated microglia cells
Han HE, et al.
Biomolecules & Therapeutics, 21, 21-21 (2013)
Rapamycin for longevity: opinion article
Blagosklonny, Mikhail V
Aging (Albany. NY.), 11, 8048-8048 (2019)
Line Heylen et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(10), 1505-1511 (2015-02-15)
Transplant recipients are at risk for invasive aspergillosis (IA), associated with a significant mortality rate. Renal transplant-specific risk factors have not been established. Forty-one adult kidney transplant recipients diagnosed with proven or probable IA from 1995 through 2013 were identified
문서
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
당사는 다양한 항생제, 항바이러스제, 항진균제와 더불어 면역체계 신호전달 표적 식별 및 검증을 위한 작용제, 길항제, 조절제 및 기타 생체 활성 저분자를 제공합니다.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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What is the Department of Transportation shipping information for this product?
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What are the extinction coefficient values for Product R0395, Rapamycin, solutions?
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The E1% extinction coefficient values in 95% ethanol at 267 nm, 277 nm and 288 nm have been reported and are listed in the product information sheet (under Documents, above).
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What is the solubility of Product R0395, Rapamycin?
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Rapamycin is soluble in DMSO and in methanol (each at 25 mg/mL) and in ethanol (2 mM). It is insoluble in water. Additional solubility information is in the product information sheet (under Documents, above).
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How should we store solutions of Product R0395, Rapamycin?
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Rokaw, M.D. et al. J. Biol. Chem. 271, 32468 (1996) described storage of a 2 mM solution of rapamycin in ethanol at -70 °C which was diluted into serum-free media before use. Unless otherwise noted for other solvents, it may be best to prepare solutions fresh and protected from light. Please refer to our product information sheet at our website.
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What is the shelf life of Product R0395, Rapamycin, as received?
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The product has a recommended retest date of 2 years but the actual recommended retest date for each lot is on the Certificate of Analysis. We guarantee the quality of the product through this date for unopened bottles stored at -20 °C.
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활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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