PZ0207

PF-04620110

≥98% (HPLC)

• 동의어(들): trans-4-[4-(4-Amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid
• 실험식(Hill 표기법): C₂₁H₂₄N₄O₄
• CAS Number: 1109276-89-2
• Molecular Weight: 396.44
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329823775
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• 저장 온도: room temp
• SMILES string: Nc1ncnc2OCCN(C(=O)c12)c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
• InChI: 1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
• InChI key: GEVVQZHMFVFGLN-HDJSIYSDSA-N

설명

생화학적/생리학적 작용

PF-04620110 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that inhibits triacylglycerol synthesis in cells and in rodents.

PF-04620110 is an orally active, selective and potent DGAT1 inhibitor.

PF-04620110 is known to regulate gut hormones.[1] Inhibition of DGAT1 might serve as a good approach for the treatment of obesity and type 2 diabetes.[2] DGAT1 inhibition might increase the oxidation of fatty acids, thus it is found to be protective against hepatic steatosis.[3]

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable