PRS4053
Anti-VISA (ab1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
동의어(들):
Anti-CARD adapter inducing interferon-beta, Anti-MAVS, Anti-Mmitochondrial antiviral signaling protein, Anti-Virus-induced signaling adapter
로그인조직 및 계약 가격 보기
크기 선택
100 μG
₩618,643
₩618,643
구입 가능 여부는 고객센터에 문의하십시오.
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
모든 사진(3)
크기 선택
보기 변경
100 μG
₩618,643
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
₩618,643
구입 가능 여부는 고객센터에 문의하십시오.
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
mouse, human, rat
기술
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAVS(57506)
일반 설명
VISA (virus-induced signalling adaptor) is also designated as MAVS (mitochondrial antiviral signalling protein). It has 540 amino acids and three main domains such as N-terminal caspase recruitment and activation domain (CARD), an internal proline-rich region and a C-terminal transmembrane (TM) domain. It is mapped to chromosome 20p13. It is intermediately expressed in all tissues and brain regions except in fetal brain.
면역원
a 13 amino acid peptide from near the amino-terminus of human VISA.
생화학적/생리학적 작용
VISA (virus-induced signalling adaptor) serves as an adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs). It activates intracellular signaling cascades, that leads to nuclear translocation of the transcription factors- IRF3 (interferon regulatory factor 3), IRF7 (interferon regulatory factor 7), and NF-κB (Nuclear factor-κB). It also helps in the formation of type I interferons (IFN-I) and proinflammatory cytokines.
결합
The action of this antibody can be blocked using blocking peptide SBP4053.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus
Zhang LK, et al.
Journal of Virology, 90(22), 10259-10270 (2016)
VISA--a pass to innate immunity
Qi B, et al.
The International Journal of Biochemistry & Cell Biology, 39(2), 287-291 (2007)
Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS)
Xing F, et al.
PLoS ONE, 11(3) (2016)
Ling Xu et al.
Journal of immunology (Baltimore, Md. : 1950), 205(8), 2091-2099 (2020-09-11)
Hepatitis C virus (HCV) infection is the cause of severe liver disease in many people. The restricted species tropism of HCV hinders the research and development of drugs and vaccines. The Chinese tree shrew (Tupaia belangeri chinensis) is a close
활성 필터
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