P9129

5-Pregnen-3β-ol-20-one

≥98%

• 동의어(들): 3β-Hydroxy-5-pregnen-20-one, Pregnenolone
• 실험식(Hill 표기법): C₂₁H₃₂O₂
• CAS Number: 145-13-1
• Molecular Weight: 316.48
• Beilstein: 2059026
• EC Number: 205-647-4
• MDL number: MFCD00003628
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24899008
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• 분석: ≥98%
• 양식: powder
• solubility: ethanol: soluble 10 mg/mL, clear, colorless to faintly yellow
• 작용기: ketone
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
• InChI: 1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
• InChI key: ORNBQBCIOKFOEO-QGVNFLHTSA-N
• 유전자 정보: human ... SERPINA6(866) ; rat ... Ar(24208)

설명

애플리케이션

5-Pregnen-3β-ol-20-one is suitable for use:

• as a substrate for 3β-HSD at a concentration of 1 μg/mL to study the time-dependent effect of reduced oxygen tension on 3β-hydroxysteroid dehydrogenase (3β-HSD) activity[1]
• as a progestin precursor to study the effects of splenic macrophages on progestin secretion of luteal cells[2]
• in the testicular interstitial cell culture medium at a concentration of 15mg/mL[3]

생화학적/생리학적 작용

One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.

Testosterone production in rats occurs in Leydig cells of the testis via the Δ⁴ pathway. Cholesterol is first converted to pregnenolone, then to progesterone, and finally to testosterone.[3] Pregnenolone is the key neurosteroid synthesized in steroidogenic glands. It is also present as a sulfate ester that serves as an antagonist of GABAergic neurons by interacting with γ-aminobutyric acid (GABA) receptor.[4]

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)