P8761

Probenecid

≥98% (NaOH, titration), powder, uricosuric agent

• 동의어(들): p-(Dipropylsulfamoyl)benzoic acid
• 실험식(Hill 표기법): C₁₃H₁₉NO₄S
• CAS Number: 57-66-9
• Molecular Weight: 285.36
• EC Number: 200-344-3
• MDL number: MFCD00038402
• UNSPSC 코드: 12161501
• PubChem Substance ID: 24898976
• NACRES: NA.77

속성

• product name: Probenecid,
• 분석: ≥98% (NaOH, titration)
• 주관자: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES string: CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
• InChI: 1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
• InChI key: DBABZHXKTCFAPX-UHFFFAOYSA-N
• 유전자 정보: human ... SLC22A11(55867) , SLC22A6(9356) , SLC22A8(9376)

설명

애플리케이션

Probenecid has been used:

• as a component of phenol red free Hank′s buffer for Intracellular Ca²⁺-mobilization assay
• as a component of calcium sensitive dye for calcium mobilization Studies
• as a supplement in Hank′s balanced salt solution (HBSS) assay buffer

Useful as an inhibitor of the organic anion transporter, MRP.

생화학적/생리학적 작용

Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves