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Merck
모든 사진(1)

문서

P8477

Sigma-Aldrich

Picotamide

동의어(들):

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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About This Item

실험식(Hill 표기법):
C21H20N4O3
CAS Number:
Molecular Weight:
376.41
EC Number:
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.83

분석

≥98%

형태

powder

solubility

ethanol: 50 mg/mL, clear, colorless to light yellow

SMILES string

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

InChI key

KYWCWBXGRWWINE-UHFFFAOYSA-N

유전자 정보

human ... TBXA2R(6915)

생화학적/생리학적 작용

Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

P L Malini et al.
Lancet (London, England), 350(9070), 15-18 (1997-07-05)
The increased prostaglandin synthesis that might follow stimulation of the arachidonic acid cascade by angiotensin-converting-enzyme inhibition (ACE-I) has been suggested to underlie the appearance of cough on ACE-I treatment. We investigated whether the prostanoid thromboxane was involved. Nine patients with
P Pancera et al.
Journal of internal medicine, 242(5), 373-376 (1998-01-04)
To assess the role of thromboxane A2 and of angiotensin II in patients with primary Raynaud's phenomenon. After an eight-day run-in period, the patients were enrolled in a single-blind, cross-over, study. Patients were examined at the Ambulatory for Microcirculatory Diseases
W Van Molle et al.
FEBS letters, 467(2-3), 201-205 (2000-02-17)
Tumor necrosis factor (TNF) induces hepatitis when injected in human beings or in rodents. The molecular mechanism by which TNF induces hepatic distress remains largely unknown, although induction of apoptosis of hepatocytes appears to be an essential step. In order
G D'Andrea et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 27 Suppl 2, S96-S99 (2006-05-12)
Migraine with aura (MwA) sufferers, at times, need specific treatments. This is the case when the auras are frequent, prolonged and cause anxiety and distress. Abnormal release of glutamate, which may trigger auras, and abnormal platelet behaviour, which constitutes a
Matthew Hotston et al.
BJU international, 106(11), 1794-1798 (2010-05-27)
To explore the possible role of of 8-isoprostane F(2α) (8-IPF(2α) ) in the aetiology of erectile dysfunction (ED), as the over-production of superoxide (O(2)(-)) derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase results in the formation of 8-IPF(2α) in vascular

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