P7443

L-α-Phosphatidylcholine

from soybean, ≥99% (TLC), lyophilized powder

• 동의어(들): 1,2-Diacyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, L-α-Lecithin, Azolectin, PC
• CAS Number: 8002-43-5
• Beilstein: 5209585
• EC Number: 232-307-2
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 생물학적 소스: soybean
• Quality Level: 200
• 분석: ≥99% (TLC)
• 양식: lyophilized powder
• 작용기: phospholipid
• 지질 유형: phosphoglycerides
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: [P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• InChI key: JLPULHDHAOZNQI-ZTIMHPMXSA-N

설명

일반 설명

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk.[1] It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes.[2] It is essential for the acetylcholine synthesis functions to nourish the brain.[1] PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD).[3] It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease.[4] PC administration therapy is effective for treating benign symmetric lipomatosis.[5]

애플리케이션

L-α-Phosphatidylcholine has been used:

• for liposome preparation[6]
• as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)[7]
• as a component of serum free substitute for whole blood cells[8]

생화학적/생리학적 작용

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.

포장

Packaged under Argon

제조 메모

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)