P7265

Prostaglandin A₁

≥98% (HPLC), powder, NF-κB inhibitor

• 동의어(들): (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA₁
• 실험식(Hill 표기법): C₂₀H₃₂O₄
• CAS Number: 14152-28-4
• Molecular Weight: 336.47
• Beilstein: 2003401
• MDL number: MFCD00077858
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24898834
• NACRES: NA.77

속성

• product name: Prostaglandin A₁, synthetic
• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥98%
• 형태: powder
• 저장 온도: −20°C
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
• InChI: 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
• InChI key: BGKHCLZFGPIKKU-LDDQNKHRSA-N

설명

생화학적/생리학적 작용

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360F
• 예방조치 성명서: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)