P6188

Prostaglandin I₂ sodium salt

≥96% (HPLC), synthetic, powder

• 동의어(들): (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt, Epoprostenol sodium salt, PGI₂-Na, Prostacyclin sodium salt
• 실험식(Hill 표기법): C₂₀H₃₁NaO₅
• CAS Number: 61849-14-7
• Molecular Weight: 374.45
• Beilstein: 6472195
• EC Number: 263-273-7
• UNSPSC 코드: 12352401
• eCl@ss: 42020658
• PubChem Substance ID: 24898653
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• 분석: ≥96% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: H₂O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.); ethanol: 50 mg/mL
• 작용기: carboxylic acid; hydroxyl
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]
• InChI: 1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1
• InChI key: OURCVRVJQMLUNA-QFDVFERUSA-M

설명

애플리케이션

Prostaglandin I2 sodium salt has been used:

• in the preparation of stock solution for platelet washing procedure[1]
• as supplement in platelet-rich-plasma, for platelet preparation[2]
• to prevent platelet activation[3]

생화학적/생리학적 작용

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A₂ and stimulating platelet adenylyl cyclase.[4] Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves