P5178

Phenobarbital sodium salt

• 동의어(들): 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate
• 실험식(Hill 표기법): C₁₂H₁₁N₂NaO₃
• CAS Number: 57-30-7
• Molecular Weight: 254.22
• Beilstein: 3802044
• EC Number: 200-322-3
• MDL number: MFCD00036211
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24898608
• NACRES: NA.77

속성

• 양식: powder
• 약물 제어: USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• solubility: H₂O: 1 g/mL; ethanol: 100 mg/mL
• 주관자: Bayer
• SMILES string: [Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2
• InChI: 1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1
• InChI key: WRLGYAWRGXKSKG-UHFFFAOYSA-M

설명

애플리케이션

Phenobarbital sodium salt has been used:

• to anesthetize mice for inducing ischemia-reperfusion injury[1]
• as a positive control for the activation of constitutive androstane receptor (CAR)[2]
• in bioluminescent yeast bioreporters (BLYAS) assay[3]

생화학적/생리학적 작용

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation.[4] It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.[5]

Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism and GABAA Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H317,H351
• 예방조치 성명서: P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges