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Merck
모든 사진(1)

주요 문서

P4374

Sigma-Aldrich

Phthalocyanine tetrasulfonate hydrate

solid

동의어(들):

29H,29H,31H-Phthalocyanine-C,C,C,C-tetrasulfonic acid, PcTS, Phthalocyanine tetrasulfonic acid, Tetrasulfophthalocyanine

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About This Item

실험식(Hill 표기법):
C32H18N8O12S4 · xH2O
CAS Number:
Molecular Weight:
834.79 (anhydrous basis)
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:

형태

solid

Quality Level

저장 조건

protect from light

색상

dark blue

저장 온도

2-8°C

SMILES string

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2

InChI key

QNPPZKALMXYKPI-UHFFFAOYSA-N

애플리케이션

Phthalocyanine tetrasulfonate hydrate has been used as a tau aggregation inhibitor (TAI) to study its effects on Tau secretion in neuroblastoma cells. It has also been used as an anionic phthalocyanine to study its effects on telomere G-quadruplex stabilization.

생화학적/생리학적 작용

Inhibitor of protein aggregation, including α-synuclein, and the formation of protease-resistant prion protein.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Maria Merezhko et al.
Cell reports, 25(8), 2027-2035 (2018-11-22)
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated misfolding of normal Tau in recipient cells.
Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Takao Ohtomo et al.
Journal of analytical methods in chemistry, 2012, 520248-520248 (2012-05-09)
The chemiluminescence (CL) signal immediately appeared when a hydrogen peroxide solution was injected into an iron-phthalocyanine tetrasulfonic acid (Fe-PTS) aqueous solution. Moreover, the CL intensity of Fe-PTS decreased by adding l-tyrosine. Based on these results, the determination of trace amounts
Eui-Nam Lee et al.
Biochemistry, 43(12), 3704-3715 (2004-03-24)
Alpha-synuclein is a pathological component of Parkinson's disease by constituting the filamentous component of Lewy bodies. Phthalocyanine (Pc) effects on the amyloidosis of alpha-synuclein have been examined. The copper complex of phthalocyanine tetrasulfonate (PcTS-Cu(2+)) caused the self-oligomerization of alpha-synuclein while

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