P0037
PP242 hydrate
≥98% (HPLC), powder
동의어(들):
2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
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모든 사진(1)
크기 선택
보기 변경
5 MG
₩479,486
About This Item
실험식(Hill 표기법):
C16H16N6O · xH2O
CAS Number:
Molecular Weight:
308.34 (anhydrous basis)
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
off-white
solubility
DMSO: >10 mg/mL
저장 온도
2-8°C
SMILES string
O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14
InChI
1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2
InChI key
FMDOLJSFPXFBIL-UHFFFAOYSA-N
애플리케이션
PP242 hydrate has been used:
- as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling [1]
- as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis [2]
- as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection [3]
생화학적/생리학적 작용
PP242 is a potent and selective mTOR inhibitor.
PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.
특징 및 장점
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
TOR signaling downregulation increases resistance to the cereal killer Fusarium graminearum
Aznar N, et al.
Plant signaling & behavior, 13(2), e1414120-e1414120 (2018)
Transient inhibition of rDNA transcription in donor cells improves ribosome biogenesis and preimplantation development of embryos derived from somatic cell nuclear transfer
Liao C, et al.
Faseb Journal, 26(12), 2774-2789 (2020)
Eleftherios Karanasios et al.
Current protocols in cytometry, 69, 12-12 (2014-07-06)
Autophagy is a membrane-trafficking pathway activated to deliver cytosolic material for degradation to lysosomes through a novel membrane compartment, the autophagosome. Fluorescence microscopy is the most common method used to visualize proteins inside cells, and it is widely used in
Min Liu et al.
Biochemical and biophysical research communications, 463(3), 255-261 (2015-05-24)
Activation of quiescent hepatic stellate cells (HSCs) is the central event of liver fibrosis. The translational machinery is an optimized molecular network that affects cellular homoeostasis and diseases, whereas the role of protein translation in HSCs activation and liver fibrosis
Néstor R Aznar et al.
Plant signaling & behavior, 13(2), e1414120-e1414120 (2017-12-12)
TOR is the master regulator of growth and development that senses energy availability. Biotic stress perturbs metabolic and energy homeostasis, making TOR a good candidate to participate in the plant response. Fusarium graminearum (Fusarium) produces important losses in many crops
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